Primary sclerosing cholangitis
Evidence: T Cell
Names
Primary sclerosing cholangitis
PSC
Chronic obliterative cholangitis
Fibrosing cholangitis
Stenosing cholangitis
Description
PSC is a rare progressive disorder of the liver which is characterized by inflammation, thickening, and abnormal formation of fibrous tissue within the passages that carry bile from the liver (bile ducts). Both bile ducts within the liver and outside the liver are affected.
Patient Groups
Bloggers
Prevalence
US Cases: 15,000 - 24,000 [Liang 2017]. Males are affected twice as often as females.
Typical Age of onset
30-40 years.
Symptoms
Fatigue
Abdominal discomfort
Itching (pruritus)
Obstructive jaundice
Malaise
Nausea
Dark Urine
Light colored stools
Enlargement of the liver and spleen
